Wang M, Zhou Y, Zong Z, et al. NLM Exp Ther Med. The final phase of treatment addresses the most damaging and deadly aspect of COVID-19: blood clots that develop in the small vessels of the lungs, as well as larger ones that can form in … We propose that the best … Join Dr. Ken Zafren to learn if COVID-19 is like high altitude pulmonary edema. The authors have declared that no competing interests exist. In high-altitude pulmonary edema (HAPE), it's theorized that vessels in the lungs constrict, causing increased pressure. doi: 10.14814/phy2.14615. This review describes COVID-19 in parallel to HAPE. The utilization of medications found to be effective in HAPE, for the treatment of COVID-19, is proposed. 2021 Jan 11:1-14. doi: 10.1080/07391102.2020.1868340. Autopsy results of a COVID-19 fatality revealed bilateral diffuse alveolar damage associated with pulmonary edema, pro-inflammatory concentrates, and indications of early-phase acute respiratory distress syndrome (ARDS). Oelz O, Maggiorini M, Ritter M, Noti C, Waber U, Vock P, Bärtsch P. Schweiz Med Wochenschr. There are some similarities between COVID-19 and HAPE as there are similarities between COVID-19 and other respiratory illnesses that cause respiratory failure: very low oxygen levels in the blood, significant difficulty breathing, the degree to which there is stiffness in the lungs, and abnormal findings on chest CT scans.  |  COVID-19 Lung Injury and High-Altitude Pulmonary Edema. On March 11, 2020, COVID-19 was declared a global pandemic due to the rapid spread across the world, with epicentres of infection in Italy, Spain, United Ki… 21,18 Among the many similarities between HAPE and COVID-19 recently described by Solaimanzadeh et al., ground glass opacities, a typical presentation of pulmonary edema, is one of them. COVID-19 Lung Injury and High Altitude Pulmonary Edema: A False Equation with Dangerous Implications. Early reports of COVID-19 symptoms and the compelling need to quickly identify treatment options and curb the growing number of critically ill patients have led to erroneous and potentially dangerous comparisons between COVID-19 and other respiratory diseases like high altitude pulmonary edema, or HAPE. Cureus. Please enable it to take advantage of the complete set of features! COVID-19 was previously known as 2019 Novel Coronavirus (2019-nCoV) respiratory disease before the World Health Organization (WHO) declared the official name as COVID-19 in February 2020. Arabi YM, Fowler R, Hayden FG. The utilization of medications found to be effective in HAPE, for the treatment of COVID-19, is proposed. This applies to both outpatient and inpatient COVID-19 treatment, and when COVID-19 is the primary diagnosis. These fundamental differences necessitate different treatment approaches. 2020;395:497–506. doi: 10.1371/journal.pone.0238552. Given the medical emergency of a growing contagion and the thousands of lives at stake, expedient attempts to improve survival are needed. Clipboard, Search History, and several other advanced features are temporarily unavailable. By May 1, 2020, the pandemic had resulted in ≈3.3 million infections, more than 235,000 deaths, and global disruption of trade. Obesity and smoking as risk factors for invasive mechanical ventilation in COVID-19: A retrospective, observational cohort study. Huang C, Wang Y, Li X, et al. This causes fluid to leak from the blood vessels to … Therapeutic options for the 2019 novel coronavirus (2019-nCoV) Li G, De Clercq E. Critical care management of adults with community-acquired severe respiratory viral infection. acetazolamide; coronavirus; covid-19; covid-2019; ground glass opacities; high altitude pulmonary edema; hypoxia; novel coronavirus; respiratory care; wuhan coronavirus. Monteiro AC, Suri R, Emeruwa IO, Stretch RJ, Cortes-Lopez RY, Sherman A, Lindsay CC, Fulcher JA, Goodman-Meza D, Sapru A, Buhr RG, Chang SY, Wang T, Qadir N. PLoS One. https://www.nature.com/articles/d41573-020-00016-0, https://www.semanticscholar.org/paper/Acute-respiratory-distress-syndrome-secondary-to-A-Ma-Wu/35750db10ab95be31bb83ae967ed4f58ae43951d. In people who develop HAPE, this response is excessive. COVID-19 Lung Injury is Not High Altitude Pulmonary Edema. Symptomatic individuals should descend 1,640 feet (500 m) to … The primary treatment of HAPE is descent to lower altitude and supplemental oxygen therapy. Effective treatments for Coronavirus Disease 2019 (COVID-19) outbreak are urgently needed. doi: 10.21203/rs.3.rs-114758/v1. Nevertheless, HAPE is entirely reversible as its mechanism is different, and there is no destruction of alveoli. Last Updated: December 17, 2020. Acetazolamide, Nifedipine and Phosphodiesterase inhibitors may be potential countermeasures. COVID-19 hypoxemia is variably attributed to ARDS, impaired HPV, and a high altitude pulmonary edema (HAPE) physiology . 2020 Aug;17(8):918-921. doi: 10.1513/AnnalsATS.202004-327CME. Both conditions have significant similarities that portend pathophysiologic trajectories. Chest X-ray. “. 2020 Sep 3;12(9):e10230. 2021 Jan;21(1):3. doi: 10.3892/etm.2020.9435. Treatment and prognosis of COVID-19: Current scenario and prospects (Review). A Although innovative treatment measures may be required for the treatment of covid-19 it is vital to examine the differences in pathophysiology before proposing similar treatments. This article appreciates clinical data published on COVID-19 in the context of another respiratory illness - high altitude pulmonary edema (HAPE). HHS Mental Health Issues in Older Adults From COVID-19 Pandemic, Naturopathic Support for an Individual with a Stoma: Case Study of an 84-Year-Old Woman with a Transverse Colostomy Resulting from Acute Intestinal Infarct, Fecal Microbiota Transplantation: An Update, Celiac Disease and Beyond: Gluten and the Immune System. Nothing is “attacking” the lungs, but the lungs show similar inflammatory symptoms to COVID, because O2 in blood is low. Both in COVID-19 and HAPE, sea level patients cannot take in enough oxygen as if they were rapidly placed on the summit of Mt. Inhaled Aviptadil for the Treatment of Moderate and Severe COVID-19 (AVIDCOVID-2) (NCT04360096) The first trial will end at an estimated enrollment of … Nifedpine and acetazolamide, two medications used to treat altitude sickness, can have dangerous consequences in COVID-19 patients. Swenson ER, Maggiorini M, Mongovin S, Gibbs JS, Greve I, Mairbäurl H, Bärtsch P. JAMA. A False Equation with Dangerous Implications. On Twitter and in his videos, Kyle-Sidell says that the symptoms of Covid-19 he has observed more closely resemble high altitude sickness than pneumonia and questions the best use of ventilators in treatment. This process fails in a condition called high-altitude pulmonary edema (HAPE), in which the lungs essentially get confused. This corrects the root cause of HAPE, hypoxic pulmonary vasoconstriction. This causes fluid to leak from the blood vessels to the lung tissues and eventually into the air sacs. There is far too much vasoconstriction and far too great a rise in pulmonary artery pressure, all of which lead fluid to leak out of the blood vessels into the lung tissue, but this occurs with no inflammation.”, “In lung injury due to COVID-19, the virus attacks the cells that make up the air sacs of the lungs. In normal lungs, air sacs (alveoli) take in oxygen and release carbon dioxide. The low oxygen levels in the atmosphere cause low oxygen levels in the air sacs of the lungs,” said Andrew Luks, MD, professor of medicine in the Division of Pulmonary, Critical Care and Sleep Medicine at Harborview Medical Center and the University of Washington. In an April 5 tweet, he wrote: “I don’t know the answer. “In all people, this leads the blood vessels in the lungs to constrict and raises the blood pressure in the lungs (pulmonary artery pressure). This site needs JavaScript to work properly. High Altitude Medicine & Biology 2020. In high-altitude pulmonary edema (HAPE), it's theorized that vessels in the lungs constrict, causing increased pressure. Immunotoxic Effects of PFCs: Implications for the COVID Vaccine? Dispense COVID-19 treatment according to government-approved protocols.  |  "Nifedipine is used to treat HAPE because it lowers the blood pressure in the lungs, which is responsible for fluid build-up in the lungs," he said. 2002 May 1;287(17):2228-35. doi: 10.1001/jama.287.17.2228. Epub 2020 Apr 13. -, Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. 2020;pbaa002. Traveler’s Diarrhea: Prevention and Treatment, New Method for Studying Mitochondrial DNA and Function, MRI May Be Able to Confirm PTSD Following Traumatic Event. eCollection 2020. There also appears to be a tendency for low carbon dioxide levels in both as well. 2020 Dec 11:rs.3.rs-114758. Everest, without time for adaptation. Dr. Luks and his co-authors warn that without careful scrutiny, misinformation can quickly spread. As a group of physicians who have in some cases cared for patients with COVID-19 and in all cases cared for patients with HAPE … Andrew M Luks, Erik R Swenson. window.addEventListener(‘LPLeadboxesReady’,function(){LPLeadboxes.addDelayedLeadbox(‘3WkyQsfbWiBakKktFPNbaV’,{delay:’15s’,views:0,dontShowFor:’1d’,domain:’ndnews.lpages.co’});}); https://ndnr.com/wp-content/uploads/2015/09/ndnr-logo-with-web1-300x169-copy.png, https://ndnr.com/wp-content/uploads/2020/05/143568211_m-scaled.jpg, Copyright Naturopathic Doctor News & Review, All Rights Reserved © 2015, Study Links Dietary Selenium and Outcome of COVID-19, Heavy Drinking Affects Decision Making the Following Day, Theme Options > General Settings > API Integrations, Emotional Response from Music Measured with Brain Scans, Word Choice Differences Between ‘Introverts’ and ‘Extroverts’, Pathophysiological Research on Link Between Inflammation and Obesity. COVID-19 has affected how the medical community shares information and what the community is learning about the disease can change quickly. Patients with HAPE also exhibit patchy infiltrates throughout the pulmonary fields, often in an asymmetric pattern and CT findings reveal increased lung markings and ground glass-like changes as well. COVID-19 Lung Injury is Not High Altitude Pulmonary Edema. HAPE patients recover when you bring them down from a high altitude and give them oxygen. Unusual observations of hospitalized COVID … Following this potential treatment options emerge. 2020 Dec 22;15(12):e0238552. These fundamental differences necessitate different treatment approaches. Order to cure disease and to heal, these relationships must be specifically considered emergency of a contagion! Emergency hape treatment covid a growing contagion and the use of cold water combined with exercise commonly... In light of this, a precision Medicine approach to managing 2019 novel in. 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